Microbiota — gestational age

A pre-term delivered infant is at greater risk for health complications. The microbiota of a pre-term baby is less stable than that of a baby born at the right term. The health risks that pre-term delivered babies face are related to the differences in the gut microbiota.

When a baby is born earlier than week 37, we talk about premature birth. A preterm delivered baby is prone to health complications, more susceptible to infections (which are more dangerous as their immune system is not ready to face them yet). We know that the microbiota can play a role in the defense against pathogens. The microbiota development is affected by the birth mode, nutrition, environment and medication. All of these factors are not only associated with the microbiota, but also with the newborn physiology, growth and development. Some infants are at higher risks of different microbiota development because of the c-section delivery, antibiotic use and formula feeding (and/or sometimes enteral feeding also). All of these are common traits for preterm delivered babies. Every one of these factors can lead to suboptimal conditions for the microbes living in the intestines, so the microbiota of a preterm born baby is less stable that that of a baby delivered in term. The immediate risks of a premature baby microbiota composition are the increased risk of sepsis and of necrotizing enterocolitis (NEC). All of these infections are life threatening for the baby. There is a direct correlation between the microbiota colonizing rate and the gestational age (meaning that the infants born at…